4-Methylbenzylamine → N-cyano-N'-(4-methylbenzyl)-3-pyridinecarboximidamide

HRID 327100Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 327100
[C:1]([N:3]=[C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)OC(C)C)#[N:2].[CH3:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1>CO>[C:1]([NH:3][C:4]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[N:21][CH2:20][C:19]1[CH:22]=[CH:23][C:16]([CH3:15])=[CH:17][CH:18]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 660354-MethylbenzylamineHCID 100812013-Pyridinecarboximidic acid, N-cyano-, 1-methylethyl ester

Produkt 1

HCID 19734558N-cyano-N'-(4-methylbenzyl)-3-pyridinecarboximidamideAusbeute 92,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Isopropyl N cyano-3-pyridinecarboximidate (0.50 g, 2.6 mmol) was dissolved in methanol (5 ml), and 4-methylbenzylamine (0.35 g, 2.9 mmol) was added. The mixture was stirred at room temperature for 30 minutes. After the reaction was completed, the reaction solution was concentrated under reduced pressure, and the concentrated residue thus obtained was crystallized from diethyl ether to give the title compound (0.60 g, 2.4 mmol, yield: 91%) as colorless powder.

Aufarbeitung

  1. concentrationthe reaction solution was concentrated under reduced pressure
  2. customthe concentrated residue thus obtained
  3. customwas crystallized from diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-adb976beb7ec413cbf46081fe9283c52
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05272164

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