Piperazin-4-ylacetophenone → 1-{4-[4-(2-Fluoro-5-nitro-benzoyl)-piperazin-1-yl]-phenyl}-ethanone

HRID 32711

Reaktionsgleichung

Reaktionsgleichung von HRID 32711
[N:1]1([C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:16][C:17]1[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][C:18]=1[C:19](O)=[O:20]>>[F:16][C:17]1[CH:25]=[CH:24][C:23]([N+:26]([O-:28])=[O:27])=[CH:22][C:18]=1[C:19]([N:4]1[CH2:5][CH2:6][N:1]([C:7]2[CH:8]=[CH:9][C:10]([C:13](=[O:15])[CH3:14])=[CH:11][CH:12]=2)[CH2:2][CH2:3]1)=[O:20]

Komponenten

3

Edukt 2

HCID 97269Piperazin-4-ylacetophenoneHCID 2809972-Fluoro-5-nitrobenzoic acid

Produkt 1

HCID 597935401-{4-[4-(2-Fluoro-5-nitro-benzoyl)-piperazin-1-yl]-phenyl}-ethanone

Versuchsvorschrift

The title compound was prepared according to the procedure described for example K step 2 from 4′-piperazino-acetophenone and 2-fluoro-5-nitrobenzoic acid (16%, yellow solid, MS (m/e): 372.1 (M+H, 100%)

Quellen und Nachweise

ORD-Eintrag
ord-5fe5988acc124388af11684098b37d86
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427612B2

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