Piperidine → HCID 19108415, Verbindung

HRID 327391

Reaktionsgleichung

Reaktionsgleichung von HRID 327391
[CH2:1]=[C:2]1[C:7](=[O:8])[CH:6]2[CH2:9][CH2:10][N:3]1[CH2:4][CH2:5]2.[NH:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>CCCCCC>[N:11]1([CH2:1][CH:2]2[C:7](=[O:8])[CH:6]3[CH2:9][CH2:10][N:3]2[CH2:4][CH2:5]3)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 3229732-Methylene-3-quinuclidone

Produkt 1

HCID 19108415HCID 19108415, VerbindungAusbeute 99,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8058HexaneLösungsmittel

Versuchsvorschrift

A reaction flask containing 2-methylenequinuclidin-3-one (6.86 g, 50 mmoles) and a magnetic stir bar was charged with piperidine (12 ml, 120 mmoles). The mixture was stirred at room temperature for 18 hours, and the mixture was added to hexane (300 ml). The solution was filtered through Celite® and the filtrate was concentrated in vacuo (maximum temperature 60° C.) to provide 11.03 g (99%) of the product as a pale yellow solid, mp 34°-37° C.

Aufarbeitung

  1. filtrationThe solution was filtered through Celite®
  2. concentrationthe filtrate was concentrated in vacuo (maximum temperature 60° C.)

Quellen und Nachweise

ORD-Eintrag
ord-bd0ee1cd5ce24034b39a8c8013ce4fb0
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05273972

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