Thionyl Chloride → 3-(1-Acetyl-4-piperidinyl)propionyl chloride

HRID 327396

Reaktionsgleichung

Reaktionsgleichung von HRID 327396
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([OH:14])=O)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].S(Cl)([Cl:17])=O>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12]([Cl:17])=[O:14])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 98557513-(1-Acetylpiperidin-4-yl)propanoic acid

Produkt 1

HCID 104659513-(1-Acetyl-4-piperidinyl)propionyl chloride

Versuchsvorschrift

To 100 ml of thionyl chloride was added 26 g of 3-(1-acetylpiperidin-4-yl)propionic acid, obtained in Reference Example 1-(2), in small portions with ice-cooling. The mixture was stirred for 5 minutes, after which the excess thionyl chloride was distilled off and the solid residue was washed with diethyl ether to give 26.4 g of 3-(1-acetylpiperidin-4-yl)propionyl chloride as a pale yellow powder.

Aufarbeitung

  1. temperaturein small portions with ice-cooling
  2. distillationafter which the excess thionyl chloride was distilled off
  3. washthe solid residue was washed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-d878f7c71dea4699bd97b412d55dc53e
Quelldatensatz
uspto-grants-1993_12
Patentnummer
US05273974

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