HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Chloro-5-(methylsulphonyl)benzoic acid → Rac-2-(3-hydroxymethyl-pyrrolidin-1-yl)-5-methanesulfonyl-benzoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Chloro-5-(methylsulphonyl)benzoic acid | HCID 2329132 | — |
| Edukt | (Pyrrolidin-3-yl)methanol | HCID 13400657 | — |
| Edukt | 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid | HCID 59793489 | — |
| Produkt | Rac-2-(3-hydroxymethyl-pyrrolidin-1-yl)-5-methanesulfonyl-benzoic acid | HCID 59793550 | 39% |
Reaktionsschritte
The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example Y) from 2-Chloro-5-methanesulfonyl-benzoic acid and rac-pyrrolidin-3-yl-methanol and obtained in 39% yield. MS (m/e): 298.1 (M−H, 100%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07427612B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-d5080999366c46b5b42605764bfd43cc |
| Quellennotiz | uspto-grants-2008_09 |