Tetrahydropyran → (E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Tetrahydropyran	HCID 8894	—
Edukt	Homophthalic anhydride	HCID 12801	—
Edukt	(E)-2-[2-(3-aminophenyl)ethenyl]-4-thiazolecarboxylic acid ethyl ester	HCID 14051204	—
Lösungsmittel	Toluene	HCID 1140	—
Produkt	(E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid	HCID 20084377	100,6%

Reaktionsschritte

A solution of 0.5 g of (E)-2-[2-(3-aminophenyl)ethenyl]-4-thiazolecarboxylic acid ethyl ester, 0.3 g of homophthalic anhydride, 15 ml of toluene and 5 ml of tetrahydropyran was heated to reflux for 0.5 hr. Upon cooling, a solid formed which was filtered to yield 0.8 g of (E)-2-[2-[3-[2-[4-(ethoxycarbonyl)-2-thiazolyl]ethenyl]phenylamino]-2-oxoethyl]benzoic acid; m.p. 221°-223° C. from ethanol.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05273986
Quelldatensatz	uspto-grants-1993_12
ORD ID	ord-287b1a368abe4273a1e9b79c8ed2fcfd
Quellennotiz	uspto-grants-1993_12