4,6-Dimethoxypyrimidine-5-carbaldehyde → 2,6-Diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	4,6-Dimethoxypyrimidine-5-carbaldehyde	HCID 4436645	—
Edukt	Carbamimidoyl-acetic acid ethyl ester	HCID 4599837	—
Lösungsmittel	Ethanol	HCID 702	—
Produkt	2,6-Diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester	HCID 70631685	56%

Reaktionsschritte

Upon heating a solution of 8.4 g 4,6-dimethoxypyrimidine-5-aldehyde and 13.0 g amidinoacetic acid ethyl ester in 150 ml ethanol for two hours, 2,6-diamino-4-(4,6-dimethoxypyrimid-5-yl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 219° C (ethanol) is obtained.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US04016277
Quelldatensatz	uspto-grants-1977_04
ORD ID	ord-08b4ebf3ee474842b90c1ffd1be5e988
Quellennotiz	uspto-grants-1977_04