Dimethylamine → HCID 86734633, Verbindung

HRID 328260Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 328260
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:14])[CH2:13][CH2:12]N[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:15][O:16][C:17]1C=C2[C:24](=[CH:25][C:26]=1[O:27][CH3:28])[C:23](=[O:29])CCC2.[CH3:30][NH:31][CH3:32].C=O.CI.C([O-])([O-])=O.[Na+].[Na+]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([OH:14])[C:13]3[C:24](=[CH:25][C:26]([O:27][CH3:28])=[C:17]([O:16][CH3:15])[CH:12]=3)[C:23](=[O:29])[CH:10]([CH2:30][N:31]3[CH2:4][CH2:3][CH2:2][CH2:7][CH2:32]3)[CH2:9]2)=[CH:4][CH:3]=1

Komponenten

8

Edukt 6

HCID 674DimethylamineHCID 712FormaldehydeHCID 6328Methyl iodideHCID 10340Sodium CarbonateHCID 382824-(4-Chlorophenyl)-4-hydroxypiperidineHCID 2668163,4-Dihydro-6,7-dimethoxy-1(2H)-naphthalenone

Produkt 1

HCID 86734633HCID 86734633, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2 g. of 4-p-chlorophenylpiperidin-4-ol are dissolved in 30 ml. of DMF. 4.05 g. of 2-dimethylaminomethyl-6,7-dimethoxy-1-tetralone methiodide, obtainable by reacting 6,7-dimethoxy-1-tetralone with dimethylamine and formaldehyde and quaternizing the product with CH3I, and 1 g. of Na2CO3 are added and the mixture is stirred for 4 hours at 20° under N2. After the customary work up, 2-(4-p-chlorophenyl-4-hydroxypiperidinomethyl-6,7-dimethoxy-1-tetralone is obtained. Hydrochloride, m.p. 227°-228°.

Quellen und Nachweise

ORD-Eintrag
ord-4062e4d4486a44bf88fb0028530d33e1
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04016281

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