Hydrochloric Acid → 2-Amino-3,3-bis(4-fluorophenyl)propanoic acid hydrochloride

HRID 32869Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 32869
C([NH:4][CH:5]([CH:9]([C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)[C:6]([OH:8])=[O:7])(=O)C.[ClH:24]>>[ClH:24].[NH2:4][CH:5]([CH:9]([C:10]1[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=1)[C:17]1[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=1)[C:6]([OH:8])=[O:7]

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 119778292-Acetylamino-3,3-bis(4-fluorophenyl)propanoic acid

Produkt 1

HCID 159809952-Amino-3,3-bis(4-fluorophenyl)propanoic acid hydrochloride

Versuchsvorschrift

A solution (144 mL) of 2-acetylamino-3,3-bis(4-fluorophenyl)propanoic acid (25.34 g, 79.9 mmol) in concentrated hydrochloric acid was stirred at 90° C. for 5 hrs, and cooled in an ice bath to allow solid precipitation. The solid was collected by filtration and dried to give the title compound (22.79 g).

Aufarbeitung

  1. temperaturecooled in an ice bath
  2. customsolid precipitation
  3. filtrationThe solid was collected by filtration
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9fa9efe74a6043d69ddcb7b315c8ad65
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07427688B2

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