5-Formylthiophene-2-Carbonitrile → [(5-Cyanothiophen-2-yl)methylideneamino]thiourea

HRID 328736

Reaktionsgleichung

Reaktionsgleichung von HRID 328736
C(C1SC(C=O)=CC=1)#N.Br.C([S:14][C:15](=[NH:26])[NH:16][N:17]=[CH:18][C:19]1[S:20][C:21]([C:24]#[N:25])=[CH:22][CH:23]=1)C=C>C(O)CO.COC>[C:24]([C:21]1[S:20][C:19]([CH:18]=[N:17][NH:16][C:15]([NH2:26])=[S:14])=[CH:23][CH:22]=1)#[N:25]

Komponenten

4

Edukt 2

HCID 122800045-Formylthiophene-2-Carbonitrile4×HCID 178419560HCID 178419560, Verbindung

Produkt 1

HCID 3033956[(5-Cyanothiophen-2-yl)methylideneamino]thiourea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21863332Dimethyl ether ethylene glycolLösungsmittel

Versuchsvorschrift

In the same manner, there were obtained with good yields: 2. 5-Cyano-thiophen-2-aldehyde-S-ethyl-isothiosemicarbazonehydroiodide melting at 145° C (free base 94° C) from 5-cyan0-thiophen-2-aldehyde and S-ethyl-isothiosemicarbazide-hydroiodide. 3. 5-Cyano-thiophen-2-aldehyde-S-n-propyl-isothiosemicarbazonehydroiodide melting at 174° C (free base 75° C) from 5-cyano-thiophen-2-aldehyde and S-n-propyl-isothiosemicarbazide-hydroiodide. 4. 5-Cyano-thiophen-2-aldehyde-S-allyl-isothiosemicarbazone-hydrobromide melting at 169° C (free base 126° C) from 5-cyano-thiophen-2-aldehyde and S-allyl-isothiosemicarbazide-hydrobromide. 5. 5-Cyano-thiophen-2 -aldehyde-S-benzyl-isothiosemicarbazonehydrobromide melting at 208° C (free base 130° C) from 5-cyano-thiophen-2-aldehyde and S-benzyl-isothiosemicarbazide-hydrobromide. 6. The above-mentioned compounds were also obtained by the reaction of 5-cyano-thiophen-2-aldehyde-thiosemicarbazone with the corresponding alkyl- or aralkyl-halides in ethylene-glycol-monomethyl ether at 50° -60° C.

Aufarbeitung

  1. customIn the same manner, there were obtained
  2. customwith good yields

Quellen und Nachweise

ORD-Eintrag
ord-10016eeba5894e59b1373c9c75dfca94
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04018792

Verknüpfte Notizen

Wird geladen…