Thionyl Chloride → Ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

HRID 328770Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 328770
S(Cl)([Cl:3])=O.O[CH2:6][CH2:7][S:8][CH:9]([CH2:21][CH2:22][CH2:23][CH:24]([O:30][C:31](=[O:33])[CH3:32])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]>C1C=CC=CC=1>[Cl:3][CH2:6][CH2:7][S:8][CH:9]([CH2:21][CH2:22][CH2:23][CH:24]([O:30][C:31](=[O:33])[CH3:32])[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18][CH2:19][CH3:20])=[O:17]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 21317600HCID 21317600, Verbindung

Produkt 1

HCID 21317532Ethyl 8-(2-chloroethylthio)-12-acetoxyheptadecanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel

Versuchsvorschrift

Thionyl chloride (13.1 g., 0.11 mole) is added dropwise with stirring to a solution of ethyl 8-(2-hydroxyethylthio)-12-acetoxyheptadecanoate (43.2 g., 0.10 mole) in benzene (150 ml.). The solution is heated at reflux for 2 hours. Then, the solvent and excess thionyl chloride are removed by evaporation in vacuo to leave the title compound as an orange yellow residual oil.

Aufarbeitung

  1. temperatureThe solution is heated
  2. temperatureat reflux for 2 hours
  3. customThen, the solvent and excess thionyl chloride are removed by evaporation in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-de56ea68853742879cd6376df4bf57e9
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04018802

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