Sodium Hydroxide → 1-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol

HRID 328889

Reaktionsgleichung

Reaktionsgleichung von HRID 328889
[CH:1]([N:4]1[CH2:7][CH:6]([OH:8])[CH2:5]1)([CH3:3])[CH3:2].[O:9]([C:16]1(O)[CH:21]=[CH:20][CH:19]=[CH:18][CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[OH-:23].[Na+]>>[O:9]([C:16]1[CH:21]=[CH:20][C:19]([O:23][CH2:5][CH:6]([OH:8])[CH2:7][NH:4][CH:1]([CH3:2])[CH3:3])=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Komponenten

4

Edukt 3

HCID 14798Sodium HydroxideHCID 5446771-(Propan-2-yl)azetidin-3-olHCID 205173521-Phenoxyphenol

Produkt 1

HCID 205173151-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanolAusbeute 58 %

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

To a mixture of 5.8 parts of 1-(iso-propyl)-3-azetidinol and 9.3 parts of 1-phenoxyphenol 0.1 part of sodium hydroxide was added, and the mixture was heated under nitrogen gas at 160° C. for 18 hours. The reaction mixture was cooled and extracted with ether. The extract was washed in water and then the solvent was distilled off. Recrystallization of the residue gave 16.1 parts of 1-(p-phenoxyphenoxy)-3-(iso-propylamino)-2-propanol having a melting point of 72°-74° C. The yield was 58%.

Aufarbeitung

  1. additionwas added
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted with ether
  4. washThe extract was washed in water
  5. distillationthe solvent was distilled off
  6. customRecrystallization of the residue

Quellen und Nachweise

ORD-Eintrag
ord-439dc4399852448982e7db8374c60e24
Quelldatensatz
uspto-grants-1977_04
Patentnummer
US04018824

Verknüpfte Notizen

Wird geladen…