Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([OH:13])=[CH:8][CH:7]=[CH:6]2.[CH:14]([N:17]1[CH2:20][CH:19]([OH:21])[CH2:18]1)([CH3:16])[CH3:15].[OH-].[K+].[ClH:24]>>[ClH:24].[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9]([O:13][CH2:20][CH:19]([OH:21])[CH2:18][NH:17][CH:14]([CH3:16])[CH3:15])=[CH:8][CH:7]=[CH:6]2Komponenten
5
Reaktionsbedingungen
- Temperatur
- 140 °C
Versuchsvorschrift
A mixture of 9.5 parts of 6-methoxy-1-naphthol, 5.8 parts of 1-(iso-propyl)-3-azetidinol and 0.3 part of potassium hydroxide was heated under nitrogen gas at 140° C. for 8 hours with agitation. The reaction mixture was treated in the same manner as in Example 1, and when the resulting hydrochloride was recrystallized from iso-propyl alcohol, there was obtained 17.7 parts of 1-(6'-methoxy-1-naphthoxy)-3-(iso-propylamino)-2-propanol hydrochloride melting at 165° - 167° C. The yield was 57.5%.
Aufarbeitung
- customwas recrystallized from iso-propyl alcohol
Quellen und Nachweise
- ORD-Eintrag
- ord-d56827fc3bf84ff481daf1a4e2331829
- Quelldatensatz
- uspto-grants-1977_04
- Patentnummer
- US04018824
Verknüpfte Notizen
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