Thiazole → 3-[7-(trans-3-Hexadecyloxytetrahydropyran-2-ylmethoxy)heptyl]thiazolium methanesulfonate
Reaktionsgleichung
[CH3:1][S:2]([O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][CH2:14][C@H:15]1[C@H:20]([O:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:19][CH2:18][CH2:17][O:16]1)(=[O:4])=[O:3].[S:38]1[CH:42]=[CH:41][N:40]=[CH:39]1>C1(C)C=CC=CC=1>[CH3:1][S:2]([O-:5])(=[O:4])=[O:3].[CH2:22]([O:21][C@@H:20]1[CH2:19][CH2:18][CH2:17][O:16][C@H:15]1[CH2:14][O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][N+:40]1[CH:41]=[CH:42][S:38][CH:39]=1)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]Komponenten
4
Versuchsvorschrift
1.20 g of the methanesulfonate [prepared as described in step (a) above] and 1.56 ml of thiazole were dissolved in 3 ml of toluene, and the solution was stirrd on an oil bath kept at 70° C. for 5 days. At the end of this time, the mixture was allowed to cool, the solvent was distilled off under reduced pressure, and the residue was subjected to column chromatography through 40 g of silica gel. 0.741 g of the title compound was obtained as a viscous oil from the fractions eluted with a 60:35:5 by volume mixture of methylene chloride, methanol and water.
Aufarbeitung
- customthe solution was stirrd on an oil bath
- temperatureto cool
- distillationthe solvent was distilled off under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-30aca703d20b46deb31f4950a25bb076
- Quelldatensatz
- uspto-grants-1990_01
- Patentnummer
- US04891363
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