4-Methyl-5-(2-hydroxyethyl)thiazole → 3-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride

HRID 330107

Reaktionsgleichung

Reaktionsgleichung von HRID 330107
[OH:1][CH2:2][CH2:3][C:4]1[S:8][CH:7]=[N:6][C:5]=1[CH3:9].[CH2:10]([Cl:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(#N)C>[Cl-:17].[CH2:10]([N+:6]1[C:5]([CH3:9])=[C:4]([CH2:3][CH2:2][OH:1])[S:8][CH:7]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Komponenten

4

Edukt 2

HCID 11364-Methyl-5-(2-hydroxyethyl)thiazoleHCID 7503Benzyl Chloride

Produkt 1

HCID 28333523-Benzyl-5-(2-hydroxyethyl)-4-methylthiazolium chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

71.6 g (500 millimoles) of 5-(2-hydroxyethyl)-4-methyl-1,3-thiazole), 63.3 g (500 millimoles) of freshly distilled benzyl chloride and 250 ml of absolute acetonitrile are refluxed for 24 hours in a 500 ml round-bottomed flask. The stirred reaction mixture is slowly cooled to room temperature, and the precipitate is filtered off under suction, washed colorless with dry acetonitrile, predried and then dried at 90° C. under reduced pressure from a water pump.

Aufarbeitung

  1. customThe stirred reaction mixture
  2. filtrationthe precipitate is filtered off under suction
  3. washwashed colorless with dry acetonitrile
  4. dry with materialdried at 90° C. under reduced pressure from a water pump

Quellen und Nachweise

ORD-Eintrag
ord-a5abeb64212d43c2b640956bcae921cb
Quelldatensatz
uspto-grants-1990_01
Patentnummer
US04894483

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