Thionyl Chloride → HCID 19869706, Verbindung

HRID 330305Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 330305
[CH2:1]([O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7]O)[CH2:2][CH3:3].S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1.N1C=CC=CC=1>[CH2:1]([O:4][C:5]1[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=1[CH2:7][Cl:15])[CH2:2][CH3:3]

Komponenten

5

Edukt 2

HCID 24386Thionyl Chloride2×HCID 12194601(2-PROPOXYPHENYL)METHANOL

Produkt 1

HCID 19869706HCID 19869706, VerbindungAusbeute 104,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineKatalysatorHCID 1140TolueneLösungsmittel2×

Versuchsvorschrift

A 2 liter flask was charged with 316 grams (1.9 moles, 1.0 eg.) of 2-propoxybenzyl alcohol and 15 grams of pyridine (0.0126 moles) in 750 ml of toluene. 237 grams (1.99 moles, 1.01 ec.) of thionyl chloride was slowly added dropwise, allowing the reaction mixture to reflux during the addition. The reaction was stirred 4 hours at room temperature after which the toluene and thionyl chloride were removed under reduced pressure. To the remaining oil was added water and ether and washed with saturated NaHCO3 Drying and removal of the solvent gave 367 grams (100% yield) of a red oil.

Aufarbeitung

  1. temperatureto reflux during the addition
  2. customwere removed under reduced pressure
  3. additionTo the remaining oil was added water and ether
  4. washwashed with saturated NaHCO3 Drying and removal of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-1887c46c178047f4904870d84746ad48
Quelldatensatz
uspto-grants-1990_01
Patentnummer
US04895865

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