(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride → 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-

HRID 330385

Reaktionsgleichung

Reaktionsgleichung von HRID 330385
CO[C@](C1C=CC=CC=1)(C(F)(F)F)C(Cl)=O.[Cl:17][CH2:18][CH:19]([OH:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:17][CH2:18][C@H:19]([OH:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

Komponenten

3

Edukt 2

HCID 3080792(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chlorideHCID 4377704Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester

Produkt 1

HCID 27344454-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-

Versuchsvorschrift

The resulting product was esterified with (R)α-methoxy-α-trifluoromethylphenylacetyl chloride, and the ester was analyzed by HPLC. From the area ratio of the chromatogram, the optical yield of the product was found to be 97.2% ee.

Quellen und Nachweise

ORD-Eintrag
ord-e77df226a15942e0a532ac81d947a918
Quelldatensatz
uspto-grants-1990_01
Patentnummer
US04895979

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