HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Naphthalene → Duloxetine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Naphthalene | HCID 931 | — |
| Edukt | 3-(N-Methylamino)-1-(2-thienyl)-1-propanol, (-)- | HCID 10095047 | — |
| Produkt | Duloxetine | HCID 60835 | — |
Reaktionsschritte
contacting the (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine with an activated naphthalene in a reaction mixture under conditions sufficient to produce (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine (Duloxetine) having the structure of formula (VIII); and (e) recovering the (3S)—N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-yl-propan-1-amine from the reaction mixture.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08877475B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-22aaffe062774d3e82cefa2a869d2bda |
| Quellennotiz | uspto-grants-2014_11 |