Pyridine → Cetilistat

HRID 330776Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 330776
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].ClC([O-])=O.Cl[C:17]([O:19][CH3:20])=O.N1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C(OCC)(=O)C.CCCCC>[CH2:17]([O:19][C:20]1[O:5][C:4](=[O:6])[C:3]2[CH:7]=[C:8]([CH3:11])[CH:9]=[CH:10][C:2]=2[N:1]=1)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:4][CH2:3][CH2:2][CH2:10][CH3:9]

Komponenten

7

Edukt 4

HCID 1049PyridineHCID 6586Methyl chloroformateHCID 762552-Amino-5-methylbenzoic acidHCID 21226386Carbonochloridate

Produkt 1

HCID 9952916CetilistatAusbeute 31 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8003PentaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-Amino-5-methylbenzoic acid (2.71 g, 17.9 mmol, 0.87 eq.) was dissolved in pyridine (24 ml) and added to the chloroformate solution prepared above. The mixture was stirred at room temperature for 1.75 hours. Methyl chloroformate (13.6 ml, 176 mmol, 8.5 eq) was added slowly, then the mixture was left to stir at ambient temperature overnight. The mixture was diluted with ethyl acetate (20 ml) and washed with water (15 ml) and 10% aqueous citric acid (20 ml). The combined aqueous phases were extracted with ethyl acetate (20 ml). The organic extracts were combined and washed with water (20 ml) and brine (20 ml) then concentrated to give a solid. This was slurried in pentane (5 ml), filtered, then slurried in acetonitrile (5 ml), filtered and purified by flash chromatography on silica (1.5% diisopropylethylamine in dichloromethane) to give a white solid (2.51 g, 31%) δH (400 MHz, CDCl3) 0.87 (3H, t, J 6.8, CH2CH3), 1.24-1.45 (26H, m, 13×CH2), 1.75-1.83 (2H, m, OCH2CH2), 2.41 (3H, s, ArCH3), 4.41 (2H, t, J 6.7, OCH2), 7.30 (1H, d, J 8.3, ArH), 7.51 (1H, dd, J 8.5, 2.0, ArH), 7.90 (1H, d, J 1.1, ArH); m/z (ES+) 402 (MH+); MPt. 72-73° C.

Aufarbeitung

  1. customprepared above
  2. waitthe mixture was left
  3. stirringto stir at ambient temperature overnight
  4. washwashed with water (15 ml) and 10% aqueous citric acid (20 ml)
  5. extractionThe combined aqueous phases were extracted with ethyl acetate (20 ml)
  6. washwashed with water (20 ml) and brine (20 ml)
  7. concentrationthen concentrated
  8. customto give a solid
  9. filtrationfiltered
  10. filtrationfiltered
  11. custompurified by flash chromatography on silica (1.5% diisopropylethylamine in dichloromethane)

Quellen und Nachweise

ORD-Eintrag
ord-5ed809e368bf401c8452030f15e6d79b
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877750B2

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