2-Bromo-1-(4-iodophenyl)ethanone → 1-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone

HRID 330818

Reaktionsgleichung

Reaktionsgleichung von HRID 330818
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)=[O:4].[CH3:12][C:13]1[N:14]=[CH:15][NH:16][CH:17]=1>C(#N)C>[I:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N:16]2[CH:17]=[C:13]([CH3:12])[N:14]=[CH:15]2)=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 2565722-Bromo-1-(4-iodophenyl)ethanoneHCID 178418800HCID 178418800, Verbindung

Produkt 1

HCID 666928261-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To 2.50 g (7.69 mmol) 2-bromo-1-(4-iodo-phenyl)-ethanone in 30 mL ACN are added 1.90 g (23.1 mmol) 4-methylimidazole and the mixture is stirred at rt for 48 h. After that time, the solvent is evaporated and the residue is taken up in EtOAc. The mixture is washed with water and brine (2×) and the organic layer is dried over magnesium sulphate. The solvent is evaporated and the residue is recrystallized from diethyl ether to yield the desired product.

Aufarbeitung

  1. customAfter that time, the solvent is evaporated
  2. washThe mixture is washed with water and brine (2×)
  3. dry with materialthe organic layer is dried over magnesium sulphate
  4. customThe solvent is evaporated
  5. customthe residue is recrystallized from diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-44e203a0e8094400a366d51e98363dcc
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877754B2

Verknüpfte Notizen

Wird geladen…