HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triphenylphosphine → HCID 51001940, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triphenylphosphine | HCID 11776 | — |
| Edukt | Diisopropyl azodicarboxylate | HCID 5363146 | — |
| Edukt | 1-Boc-4-(3-hydroxypropyl)piperazine | HCID 16217800 | — |
| Edukt | 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one | HCID 70306176 | — |
| Edukt | 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one | HCID 70317432 | — |
| Produkt | HCID 51001940 | HCID 51001940 | 85% |
Reaktionsschritte
The procedure of Step 6 of Example 1 was repeated except for using 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, t-butyl 4-(3-hydroxypropyl)piperazine-1-carboxylate (2.0 eq) instead of 4-(2-hydroxyethyl)morpholine, using 2 equivalents of PPh3 and DIAD, and being stirred for 19 h to obtain the title compound (85%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08877747B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-6eb869b9134e49538db3bc4426d2820c |
| Quellennotiz | uspto-grants-2014_11 |