Hydrochloric Acid → HCID 67972354, Verbindung

HRID 331402Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 331402
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[C:19]3[CH:20]=[CH:21][O:22][C:18]=3[C:17]([F:23])=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>ClCCl>[ClH:24].[F:23][C:17]1[C:18]2[O:22][CH:21]=[CH:20][C:19]=2[C:14]([C:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=2)=[CH:15][CH:16]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 67972151HCID 67972151, Verbindung

Produkt 1

HCID 67972354HCID 67972354, VerbindungAusbeute 90,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of 4-(7-fluoro-benzofuran-4-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (0.97 g, 3.06 mmol) in dichloromethane (23 ml) was added at room temperature hydrochloric acid solution (4M in dioxane, 11.5 ml, 45.8 mmol) and the reaction mixture was allowed to stir for 1.5 h. The reaction mixture was evaporated, the residue triturated with diethyl ether (50 ml) and MeOH (1 ml), the precipitate was collected by filtration, washed with diethyl ether and dried to yield 4-(7-fluoro-benzofuran-4-yl)-1,2,3,6-tetrahydro-pyridine hydrochloride as light yellow solid (0.7 g, 90%), MS (ISP) m/z=218.2 [(M+H)+], mp 202° C.

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. customthe residue triturated with diethyl ether (50 ml) and MeOH (1 ml)
  3. filtrationthe precipitate was collected by filtration
  4. washwashed with diethyl ether
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-7a85168600c54b748b4af98cbd512ab5
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877778B2

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