Methoxyacetic Acid → HCID 178496455, Verbindung
Reaktionsgleichung
Cl.Cl.[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:25][CH2:24][C@H:23]([NH2:26])[CH2:22][CH2:21]2)[CH:5]=[CH:4]1.[CH3:27][O:28][CH2:29][C:30](O)=[O:31]>>[O:3]1[C:8]2=[CH:9][CH:10]=[CH:11][C:7]2=[C:6]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][N:13]2[CH2:18][CH2:19][C@H:20]2[CH2:21][CH2:22][C@H:23]([NH:26][C:30](=[O:31])[CH2:29][O:28][CH3:27])[CH2:24][CH2:25]2)[CH:5]=[CH:4]1Komponenten
3
Versuchsvorschrift
The title compound, off-white solid (96 mg, 84%), MS (ISP) m/z=399.4 [(M+H)+], mp 124° C., was prepared in accordance with the general method of example 1 from trans-4-[2-(4-benzofuran-4-yl-piperidin-1-yl)-ethyl]-cyclohexyl-amine dihydrochloride (intermediate A) (115 mg, 0.29 mmol) and methoxy-acetic acid.
Quellen und Nachweise
- ORD-Eintrag
- ord-b60a7ddcc18e4f2387a1b2d590cbb353
- Quelldatensatz
- uspto-grants-2014_11