2-Isobutoxy-5-methanesulfonyl-benzoic acid → (4-Benzoxazol-2-yl-piperazin-1-yl)-(2-isobutoxy-5-methanesulfonyl-phenyl)-methanone
Reaktionsgleichung
[CH2:1]([O:5][C:6]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:7]=1[C:8]([OH:10])=O)[CH:2]([CH3:4])[CH3:3].Cl.[N:20]1([C:26]2[O:27][C:28]3[CH:34]=[CH:33][CH:32]=[CH:31][C:29]=3[N:30]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[O:27]1[C:28]2[CH:34]=[CH:33][CH:32]=[CH:31][C:29]=2[N:30]=[C:26]1[N:20]1[CH2:21][CH2:22][N:23]([C:8]([C:7]2[CH:11]=[C:12]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:13]=[CH:14][C:6]=2[O:5][CH2:1][CH:2]([CH3:3])[CH3:4])=[O:10])[CH2:24][CH2:25]1Komponenten
3
Versuchsvorschrift
Prepared in analogy to example 1.1 b) from 2-isobutoxy-5-methanesulfonyl-benzoic acid (Example 2.4) and 2-piperazin-1-yl-benzoxazole hydrochloride. The crude material was purified by chromatography (SiO2, ethyl acetate) to yield the title compound as a slightly yellow solid.
Aufarbeitung
- customThe crude material was purified by chromatography (SiO2, ethyl acetate)