Piperazine → 6-Methoxy-2-(piperazin-1-yl)benzo[d]thiazole

HRID 33150Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 33150
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.C(N(CC)CC)C>O1CCCC1>[CH3:12][O:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[S:3][C:4]=2[CH:10]=1

Komponenten

5

Edukt 3

HCID 4837PiperazineHCID 8471TriethylamineHCID 2731322-Chloro-6-methoxybenzothiazole

Produkt 1

HCID 220289286-Methoxy-2-(piperazin-1-yl)benzo[d]thiazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

A mixture of 1.50 mmol 2-chloro-6-methoxybenzothiazole (CA=[2605-14-3]), 4.51 mmol of piperazine and 4.51 mmol of triethylamine in 5 ml of tetrahydrofuran in a sealed tube was heated at 160° C. for 5 min under microwave irradiation. The reaction mixture was concentrated, and the residue was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white solid.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by chromatography (SiO2, methanol/dichloromethane)

Quellen und Nachweise

ORD-Eintrag
ord-4ce638ede920459788236469969376ab
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429585B2

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