HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Prolinol, (R)- → ((R)-2-Hydroxymethyl-pyrrolidin-1-yl)-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-methanone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Prolinol, (R)- | HCID 2724541 | — |
| Edukt | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester | HCID 66599292 | — |
| Produkt | ((R)-2-Hydroxymethyl-pyrrolidin-1-yl)-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-methanone | HCID 42629928 | 96% |
Reaktionsschritte
As described for example 223, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (120 mg, 0.37 mmol) was converted, using D-prolinol instead of L-prolinol, to the title compound (139 mg, 96%) which was obtained as a colourless oil. MS: m/e=394.1 [M+H]′.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08877782B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-e51d18291c3c4340a7373ceaec328927 |
| Quellennotiz | uspto-grants-2014_11 |