Ethyl 3-(4-fluorophenyl)-1,2-oxazole-4-carboxylate → 3-(4-Chlorophenyl)-1,2-oxazole-4-carboxylic acid
Reaktionsgleichung
C([O:3][C:4]([C:6]1[C:7]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[N:8][O:9][CH:10]=1)=[O:5])C.C(OC(C1C(C2C=CC(F)=CC=2)=NOC=1)=O)C>>[Cl:17][C:14]1[CH:13]=[CH:12][C:11]([C:7]2[C:6]([C:4]([OH:5])=[O:3])=[CH:10][O:9][N:8]=2)=[CH:16][CH:15]=1Komponenten
3
Versuchsvorschrift
As described for example 323d, 3-(4-chloro-phenyl)-isoxazole-4-carboxylic acid ethyl ester (57.0 g, 226.5 mmol) was converted, instead of 3-(4-fluoro-phenyl)-isoxazole-4-carboxylic acid ethyl ester, to the title compound (50.7 g, 92%) which was obtained as a light yellow solid. MS: m/e=222.3 [M−H]−.
Quellen und Nachweise
- ORD-Eintrag
- ord-68334570f1c6441883bdbc557fdcf642
- Quelldatensatz
- uspto-grants-2014_11
- Patentnummer
- US08877782B2
Notizen zur Reaktion
Wird geladen…