Magnesium chloride hexahydrate → Vildagliptin Magnesium(II)-Chloride

HRID 332076

Reaktionsgleichung

Reaktionsgleichung von HRID 332076
O.O.O.O.O.O.[Cl-:7].[Mg+2:8].[Cl-].[CH2:10]1[CH2:14][N:13]([C:15]([CH2:17][NH:18][C:19]23[CH2:28][C:26]4([OH:29])[CH2:27][CH:21]([CH2:22][CH:23]([CH2:25]4)[CH2:24]2)[CH2:20]3)=[O:16])[C@H:12]([C:30]#[N:31])[CH2:11]1>CC(O)C>[CH2:10]1[CH2:14][N:13]([C:15]([CH2:17][NH:18][C:19]23[CH2:28][C:26]4([OH:29])[CH2:25][CH:23]([CH2:22][CH:21]([CH2:27]4)[CH2:20]2)[CH2:24]3)=[O:16])[C@H:12]([C:30]#[N:31])[CH2:11]1.[Cl-:7].[Mg+2:8].[Cl-:7]

Komponenten

4

Edukt 2

HCID 24644Magnesium chloride hexahydrateHCID 6918537Vildagliptin

Produkt 1

HCID 86675510Vildagliptin Magnesium(II)-Chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

0.34 g (1.65 mmole) of magnesium(II)-chloride hexahydrate is dissolved in 15 cm3 of 2-propanol at 50° C. under intensive stirring, and 1.0 g (3.3 mmole) of vildagliptin base is added to the solution. The solution is stirred at room temperature for 2 hours and is subsequently evaporated. The remaining crystalline product is washed with propanol and dried.

Aufarbeitung

  1. additionis added to the solution
  2. customis subsequently evaporated
  3. washThe remaining crystalline product is washed with propanol
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-c451687bab2a46079dfc833dbed04ae3
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877799B2

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