Methylamine → 4-[1,3]Dioxan-2-yl-N-methyl-butyramide

To 4-[1,3]dioxan-2-yl-butyric acid (2.55 g, 0.015 mol) in dichloromethane (200 ml) was added methylamine (2M in THF, 8.1 ml, 0.016 mol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (3.09 g, 0.016 mol) and hydroxybenzotriazole (2.16 g, 0.016 mol) and the mixture stirred at room temperature overnight. The organic layer was washed with saturated sodium bicarbonate solution (200 ml) and the aqueous layer extracted with dichloromethane (4×50 ml). The combined organics were dried (Na2SO4) and evaporated to give a colourless oil (3.2 g)

1. washThe organic layer was washed with saturated sodium bicarbonate solution (200 ml)
2. extractionthe aqueous layer extracted with dichloromethane (4×50 ml)
3. dry with materialThe combined organics were dried (Na2SO4)
4. customevaporated

ORD-Eintrag

ord-45ea3b8591ff4b7bb3fddd7fcac0af8f

Quelldatensatz

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07429579B2