HCID 69315260, Verbindung → 6-[5-(3-[1,3]Dioxan-2-yl-propyl)-4-methyl-4H-[1,2,4]triazol-3-yl]-2-methyl-quinoline

HRID 33226Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 33226
[O:1]1[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[CH2:7][CH2:8][CH2:9][C:10]([NH:13][NH:14][C:15]([C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[N:23]=[C:22]([CH3:27])[CH:21]=[CH:20]2)=O)=[N:11][CH3:12]>C(OCC)(=O)C>[O:1]1[CH2:6][CH2:5][CH2:4][O:3][CH:2]1[CH2:7][CH2:8][CH2:9][C:10]1[N:11]([CH3:12])[C:15]([C:17]2[CH:18]=[C:19]3[C:24](=[CH:25][CH:26]=2)[N:23]=[C:22]([CH3:27])[CH:21]=[CH:20]3)=[N:14][N:13]=1

Komponenten

3

Edukt 1

HCID 69315260HCID 69315260, Verbindung

Produkt 1

HCID 693120036-[5-(3-[1,3]Dioxan-2-yl-propyl)-4-methyl-4H-[1,2,4]triazol-3-yl]-2-methyl-quinolineAusbeute 10 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

2-Methyl-quinoline-6-carboxylic acid N′-(4-[1,3] dioxan-2-yl-1-methylimino-butyl)-hydrazide (1.28 g, 3.4 mmol) was heated in ethyl acetate (20 ml) for 4 h. The solvent was evaporated and the residue was purified by silica gel chromatography (eluent 20% MeOH:EtOAc) which gave the title compound as a brown solid (109 mg, 10%).

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue was purified by silica gel chromatography (eluent 20% MeOH:EtOAc) which

Quellen und Nachweise

ORD-Eintrag
ord-f03a2948203c4a89bd29e13ea5051a23
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429579B2

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