Bis(2-pyridylmethyl)amine → HCID 57773596, Verbindung

HRID 333114

Reaktionsgleichung

Reaktionsgleichung von HRID 333114
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([NH2:13])(=[O:12])=[O:11])=[CH:6][CH:5]=1)=[C:2]=[S:3].[N:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][NH:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1>C(#N)C>[N:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][N:21]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1)[C:2](=[S:3])[NH:1][C:4]1[CH:5]=[CH:6][C:7]([S:10]([NH2:13])(=[O:11])=[O:12])=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 73759Bis(2-pyridylmethyl)amineHCID 5213594-Isothiocyanatobenzenesulfonamide

Produkt 1

HCID 57773596HCID 57773596, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

To a suspension of 4-isothiocyanatobenzenesulfonamide (401 mg, 1.87 mmol) in dry acetonitrile (10 mL) was added bis(pyridin-2-ylmethyl)amine (373 mg, 1.87 mmol). The reaction mixture went clear and a white precipitate formed. The solid was filtered, washed with acetonitrile and dried to afford MIP-1138 as a white sold (710 mg, 92%). 1H NMR (400 MHz, DMSO-d6) δ 11.18 (s, 1H), 8.61 (br, 2H), 7.79-7.64 (m, 6H), 7.34-7.25 (m, 6H), 5.14 (br, 4H); (M+H)+ (414).

Aufarbeitung

  1. customa white precipitate formed
  2. filtrationThe solid was filtered
  3. washwashed with acetonitrile
  4. customdried
  5. customto afford MIP-1138 as

Quellen und Nachweise

ORD-Eintrag
ord-b8a46b0d2b754cad82fe4814cb5ef06b
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877970B2

Verknüpfte Notizen

Wird geladen…