4-Iodobenzoyl chloride → HCID 68861098, Verbindung

HRID 333124

Reaktionsgleichung

Reaktionsgleichung von HRID 333124
[NH2:1][C:2]1[S:6][C:5]([S:7]([NH2:10])(=[O:9])=[O:8])=[N:4][N:3]=1.[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][CH:13]=1>N1C=CC=CC=1>[I:11][C:12]1[CH:20]=[CH:19][C:15]([C:16]([NH:1][C:2]2[S:6][C:5]([S:7](=[O:9])(=[O:8])[NH2:10])=[N:4][N:3]=2)=[O:17])=[CH:14][CH:13]=1

Komponenten

4

Edukt 2

HCID 743734-Iodobenzoyl chlorideHCID 847245-Amino-1,3,4-thiadiazole-2-sulfonamide

Produkt 1

HCID 68861098HCID 68861098, VerbindungAusbeute 13,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

To a solution of 5-amino-1,3,4-thiadiazole-2-sulfonamide (0.133 g, 0.50 mmol) in pyridine (5.0 mL) was added 4-iodobenzoyl chloride (0.162 g, 0.75 mmol). The reaction mixture was stirred at room temperature for overnight under nitrogen. Solvent was concentrated and water (60 mL) was added the mixture. The precipitated sulfonamide was filtered and dried over vacuum to give desired compound (27.3 mg, 13%) as a white solid.

Aufarbeitung

  1. concentrationSolvent was concentrated
  2. additionwater (60 mL) was added the mixture
  3. filtrationThe precipitated sulfonamide was filtered
  4. customdried over vacuum

Quellen und Nachweise

ORD-Eintrag
ord-250ae31a92204fd3b323f242a4f44623
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877970B2

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