Trifluoroacetic acid → HCID 178511761, Verbindung

HRID 333338Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 333338
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][C@H:15]([NH:21]C(=O)OC(C)(C)C)[C:16]3[NH:20][N:19]=[N:18][N:17]=3)=[CH:10][CH:9]=2)[CH:5]=[CH:6][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:9]=[CH:10][C:11]([CH2:14][C@@H:15]([C:16]3[NH:20][N:19]=[N:18][N:17]=3)[NH2:21])=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 178454141(S)-Tert-butyl 2-(3'-chlorobiphenyl-4-yl)-1-(1H-tetrazol-5-yl)ethylcarbamate

Produkt 1

HCID 178511761HCID 178511761, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (S)-tert-butyl 2-(3′-chlorobiphenyl-4-yl)-1-(1H-tetrazol-5-yl)ethylcarbamate (250 mg, 0.625 mmol) in DCM (5 ml) at room temperature was added TFA (2 ml, 26.0 mmol), and the mixture was stirred at room temperature for 0.5 hour. The mixture was concentrated under reduced pressure and obtained the title compound. LCMS (condition A): 300.1 (M+1); retention time=1.20 min.

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6dfb14583bc747ca8fac8a37b3df17bb
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877815B2

Notizen zur Reaktion

Wird geladen…