Methanol → 4-Hydroxy-5,5-dimethyl-2(5H)-furanone

HRID 333361

Reaktionsgleichung

Reaktionsgleichung von HRID 333361
[CH3:1][C:2]1([CH3:13])[O:6][C:5](=[O:7])[CH:4]=[C:3]1N1CCCC1.C[OH:15]>Cl>[OH:15][C:3]1[C:2]([CH3:13])([CH3:1])[O:6][C:5](=[O:7])[CH:4]=1

Komponenten

4

Edukt 2

HCID 887MethanolHCID 252473365,5-dimethyl-4-(pyrrolidin-1-yl)furan-2(5H)-one

Produkt 1

HCID 547201394-Hydroxy-5,5-dimethyl-2(5H)-furanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Reaktionsbedingungen

Temperatur
88 °C

Versuchsvorschrift

A suspension of 5,5-dimethyl-4-pyrrolidin-1-ylfuran-2(5H)-one (535 mg) in a mixture of MeOH (2 mL) and 5M HCl (8 mL) was heated at 88° C. for 2 hours. The mixture was cooled to room temp., extracted with CHCl3 (10×15 mL), combined, dried over Na2SO4, and evaporated to dryness to give 4-hydroxy-5,5-dimethyl-5H-furan-2-one as light brown solid. Yield: 359 mg, 95%.

Aufarbeitung

  1. temperatureThe mixture was cooled to room temp.
  2. extractionextracted with CHCl3 (10×15 mL)
  3. dry with materialdried over Na2SO4
  4. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-6057f08f280d40e299280dbdc5fb3106
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877923B2

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