Hydrochloric Acid → ((S)-1-{(S)-2-[4-(4'-{[6-((2R,5S)-2,5-Dimethyl-piperazin-1-yl)-pyridine-3-carbonyl]-amino}-2'-trifluoromethoxy-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

HRID 333495Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 333495
C(Cl)(=O)C.Cl.C(OC([N:13]1[CH2:18][C@@H:17]([CH3:19])[N:16]([C:20]2[CH:25]=[CH:24][C:23]([C:26](=[O:66])[NH:27][C:28]3[CH:33]=[CH:32][C:31]([C:34]4[CH:39]=[CH:38][C:37]([C:40]5[N:41]=[C:42]([C@@H:45]6[CH2:49][CH2:48][CH2:47][N:46]6[C:50](=[O:60])[C@@H:51]([NH:55][C:56]([O:58][CH3:59])=[O:57])[CH:52]([CH3:54])[CH3:53])[NH:43][CH:44]=5)=[CH:36][CH:35]=4)=[C:30]([O:61][C:62]([F:65])([F:64])[F:63])[CH:29]=3)=[CH:22][N:21]=2)[CH2:15][C@@H:14]1[CH3:67])=O)(C)(C)C>C(O)C>[CH3:59][O:58][C:56](=[O:57])[NH:55][C@H:51]([C:50]([N:46]1[CH2:47][CH2:48][CH2:49][C@H:45]1[C:42]1[NH:43][CH:44]=[C:40]([C:37]2[CH:38]=[CH:39][C:34]([C:31]3[CH:32]=[CH:33][C:28]([NH:27][C:26]([C:23]4[CH:22]=[N:21][C:20]([N:16]5[CH2:15][C@H:14]([CH3:67])[NH:13][CH2:18][C@H:17]5[CH3:19])=[CH:25][CH:24]=4)=[O:66])=[CH:29][C:30]=3[O:61][C:62]([F:65])([F:63])[F:64])=[CH:35][CH:36]=2)[N:41]=1)=[O:60])[CH:52]([CH3:53])[CH3:54]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 178502387HCID 178502387, Verbindung

Produkt 1

HCID 178502383((S)-1-{(S)-2-[4-(4'-{[6-((2R,5S)-2,5-Dimethyl-piperazin-1-yl)-pyridine-3-carbonyl]-amino}-2'-trifluoromethoxy-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

Acetyl chloride (63.2 mL, 888 mmol) was added to ethanol (360 mL) and stirred at RT for 1 h. To the resulting HCl solution was added a solution of (2S,5R)-4-[5-(4′-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-1H-imidazol-4-yl}-2-trifluoromethoxy-biphenyl-4-ylcarbamoyl)-pyridin-2-yl]-2,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (73 g, 84 mmol) in ethanol (360 mL). The reaction mixture was stirred at RT overnight.

Aufarbeitung

  1. stirringThe reaction mixture was stirred at RT overnight

Quellen und Nachweise

ORD-Eintrag
ord-6246fbc25cae491dae68fa83c68292a1
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883135B2

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