Methylamine → 3-Iodo-N-methylpyridin-2-amine
Reaktionsgleichung
F[C:2]1[C:7]([I:8])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:9][NH2:10]>>[I:8][C:7]1[C:2]([NH:10][CH3:9])=[N:3][CH:4]=[CH:5][CH:6]=1Komponenten
3
Versuchsvorschrift
A 1 L round bottom flask was charged with 2-fluoro-3-iodopyridine (27.0 g, 121 mmol) and 500 mL of 40% aqueous solution of methylamine. This was stirred at reflux for 4 h before being cooled to ambient temperature. The product was extracted with dichloromethane. Evaporation of the dichloromethane gave 3-iodo-N-methylpyridin-2-amine (26.8 g, 95% yield).
Aufarbeitung
- temperatureat reflux for 4 h
- extractionThe product was extracted with dichloromethane
- customEvaporation of the dichloromethane
Quellen und Nachweise
- ORD-Eintrag
- ord-a99fea72260e4f50968c688851281af9
- Quelldatensatz
- uspto-grants-2014_11
- Patentnummer
- US08883322B2
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