2-Methoxybenzoyl chloride → HCID 59026631, Verbindung

HRID 333705Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 333705
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[S:4][C:3]=1[C:14]#[N:15].[CH3:16][O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>N1C=CC=CC=1>[C:14]([C:3]1[S:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)=[CH:6][C:2]=1[NH:1][C:20](=[O:21])[C:19]1[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=1[O:17][CH3:16])#[N:15]

Komponenten

4

Edukt 2

HCID 889692-Methoxybenzoyl chlorideHCID 27358943-Amino-5-(4-fluorophenyl)thiophene-2-carbonitrile

Produkt 1

HCID 59026631HCID 59026631, VerbindungAusbeute 74 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

A solution of 3-amino-5-(4-fluorophenyl)thiophene-2-carbonitrile (2.0 g, 9.2 mmol) in pyridine (40 mL) was cooled in an ice bath, and 2-methoxybenzoyl chloride (1.2 mL, 9.2 mmol) was added dropwise. The cooling bath was removed, and the reaction was stirred for 16 h. The reaction was poured into water, and the resulting suspension was acidified with 1 M hydrochloric acid. The solid was filtered, washed with water, and dried under vacuum to give N-(2-cyano-5-(4-fluorophenyl)thiophen-3-yl)-2-methoxybenzamide (2.4 g, 74% yield).

Aufarbeitung

  1. customThe cooling bath was removed
  2. additionThe reaction was poured into water
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-30b0592c3f954f3bae612b0fd9ec7d79
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883781B2

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