3-(3-methyl-3-nitro-butyl)-3H-benzoxazol-2-one → 3-(3-amino-3-methyl-butyl)-3H-benzoxazol-2-one

Beteiligte Stoffe

Reaktionsschritte

11.0 g 3-(3-methyl-3-nitro-butyl)-3H-benzoxazol-2-one from the reaction described above are dissolved in 130 mL ethanol and hydrogenated with Raney nickel as catalyst at 5 bar for 20 hours. The catalyst is filtered off and the filtrate is freed from the solvent. 10% ethanolic hydrochloric acid is added, the solvent is distilled off and the residue is stirred in an acetone/diethyl ether mixture. White solid. Yield: 6.0 g (77% over 2 steps, hydrochloride); melting range=145-147° C.

Herkunft & Nachweise