Ammonia → HCID 178420422, Verbindung

HRID 333749

Reaktionsgleichung

Reaktionsgleichung von HRID 333749
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C:12](O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:15][C:16]1[C:21]([NH2:22])=[CH:20][CH:19]=[CH:18][N:17]=1.N>>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]1[NH:15][C:16]2=[N:17][CH:18]=[CH:19][CH:20]=[C:21]2[N:22]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 222AmmoniaHCID 99562,3-DiaminopyridineHCID 5622014-(Benzyloxy)butanoic acid

Produkt 1

HCID 178420422HCID 178420422, VerbindungAusbeute 86 %

Versuchsvorschrift

4-(Benzyloxy)butanoic acid (5.0 g) and 2,3-diaminopyridine (1.12 g) were stirred at 150° C. for 10 hr. Under ice-cooling, to the reaction mixture was added concentrated aqueous ammonia, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (2.36 g).

Aufarbeitung

  1. temperatureUnder ice-cooling, to the reaction mixture
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-257fd407c9e749c5858e8bd50352b094
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883788B2

Verknüpfte Notizen

Wird geladen…