Phosphorus oxide (P4O10) → Ethyl (E)-4,4,5,5,5-pentafluoropent-2-enoate

HRID 333953Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 333953
[F:1][C:2]([F:15])([C:11]([F:14])([F:13])[F:12])[CH:3](O)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>>[F:1][C:2]([F:15])([C:11]([F:12])([F:13])[F:14])/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Komponenten

3

Edukt 2

HCID 14812Phosphorus oxide (P4O10)HCID 21883573Ethyl 4,4,5,5,5-pentafluoro-3-hydroxypentanoate

Produkt 1

HCID 15260846Ethyl (E)-4,4,5,5,5-pentafluoropent-2-enoate

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

Ethyl 4,4,5,5,5-pentafluoro-3-hydroxy-pentanoate (11.9 g from step C) was placed in a 25 ml round-bottom flask and phosphorpentoxid was added in small portions until the educt was almost completely absorbed. The temperature was raised slowly to 140° C. until a brown syrup was obtained. The flask was connected to a distilling apparatus and the product isolated by distillation at reduced pressure (50 mbar, 50° C.). 5.5 g (25.2 mmol, 50% over 2 steps) were obtained which were used directly in the next step.

Aufarbeitung

  1. customwas almost completely absorbed
  2. customwas obtained
  3. customthe product isolated by distillation at reduced pressure (50 mbar, 50° C.)
  4. custom5.5 g (25.2 mmol, 50% over 2 steps) were obtained which

Quellen und Nachweise

ORD-Eintrag
ord-79032a1d84ae4d9f8b79cf1f57bf3fc5
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883791B2

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