Piperazine → 2-Methyl-4-piperazin-1-yl-7-(trifluoromethyl)quinoline

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

2-Methyl-4-chloro-7-(trifluoromethyl)quinoline (1.1 g, 4.4 mmol) was dissolved in dipropyleneglycolmonomethylether, piperazine was added (12 g, 14 mmol) and the mixture was stirred at 140° C. overnight. The solvent was removed under reduced pressure and the residue purified by column chromatography (prepacked silica column, gradient ethyl acetate/methanol with the addition of 1% ammonia) to yield 1.07 g of a solid. (3.6 mmol, 82%) MS (APCI): m/z=295.8 [M+1]+.

Herkunft & Nachweise