Trifluoroacetic acid → 5-Methoxy-7-piperazin-1-yl-pyrazolo[1,5-a]pyrimidine
Reaktionsgleichung
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[N:6]2[N:22]=[CH:23][CH:24]=[C:5]2[N:4]=1.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[N:6]2[N:22]=[CH:23][CH:24]=[C:5]2[N:4]=1Komponenten
4
Versuchsvorschrift
tert-Butyl 4-(5-methoxy-pyrazolo[1,5-a]pyrimidin-7-yl)piperazine-1-carboxylate (1.186 g, 3.56 mmol) was stirred for 10 minutes at room temperature in a 1:1 mixture of dichloromethane and trifluoroacetic acid. The mixture was evaporated to dryness under reduced pressure, the residue was dissolved in water, the resulting solution was washed with dichloromethane, basified with 4M NaOH and extracted with dichloromethane (3×). The combined organic phases were washed with water, dried over magnesium sulfate and the solvent was removed under reduced pressure to yield 624 mg of a solid (2.68 mmol, 75%). MS (APCI): m/z=234.1 [M+1]+.