Sodium Hydroxide → 1-Cyclopropyl-isoquinoline-3-carboxylic acid
Reaktionsgleichung
C[O:2][C:3]([C:5]1[N:6]=[C:7]([CH:15]2[CH2:17][CH2:16]2)[C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4].[OH-].[Na+]>CO>[CH:15]1([C:7]2[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:14]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=2)[CH2:16][CH2:17]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
350 mg (1.54 mmol) 1-cyclopropyl-isoquinoline-3-carboxylic acid methyl ester was dissolved in 10 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation, the residue taken up in water, acidified with 4 M aqueous hydrochlorid acid and extracted with EtOAc. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo.