Methanol → 2-Chloro-6-methoxypyridin-4-amine

HRID 334057

Reaktionsgleichung

Reaktionsgleichung von HRID 334057
[Na].[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5](Cl)[N:4]=1.[CH3:11][OH:12]>>[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5]([O:12][CH3:11])[N:4]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1376524-Amino-2,6-dichloropyridineHCID 5360545Sodium

Produkt 1

HCID 713025122-Chloro-6-methoxypyridin-4-amine

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

To a solution of 1.84 g (44.0 mmol) sodium in 40 mL MeOH was added 6.72 g (40.0 mmol) 2,6-dichloro-pyridin-4-ylamine. The reaction mixture was stirred at 150° C. for 30 min under microwave irradiation. The solvent was evaporated and ice water was added. The precipitate was filtered off, washed with water and dried.

Aufarbeitung

  1. customThe solvent was evaporated
  2. additionice water was added
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-6e476dc327cb4e6db5cc1ade55d580b7
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883789B2

Verknüpfte Notizen

Wird geladen…