Sodium Hydroxide → 4-Bromo-6-methoxy-2-pyridinecarboxylic acid

HRID 334058Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 334058
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([Br:11])[CH:8]=[C:7]([O:12][CH3:13])[N:6]=1)=[O:4].[OH-].[Na+]>CO>[Br:11][C:9]1[CH:8]=[C:7]([O:12][CH3:13])[N:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:10]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 86688282Methyl 4-bromo-6-methoxypicolinate

Produkt 1

HCID 155103794-Bromo-6-methoxy-2-pyridinecarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

246 mg (1.00 mmol) 4-bromo-6-methoxy-pyridine-2-carboxylic acid methyl ester was dissolved in 5 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation. the residue was taken up in water and acidified with 4 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and dried.

Aufarbeitung

  1. customThe solvent was removed by distillation
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-cb2239ce1f4c4526bc894a4439b55e38
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883789B2

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