Sodium Hydroxide → HCID 84696473, Verbindung

HRID 334059Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 334059
C[O:2][C:3]([C:5]1[N:6]=[C:7]([O:17][CH3:18])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH3:16])=[CH:10][CH:9]=2)=[O:4].[OH-].[Na+]>CO>[CH3:18][O:17][C:7]1[C:8]2[C:13](=[CH:12][C:11]([O:15][CH3:16])=[CH:10][CH:9]=2)[CH:14]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 866882833-Isoquinolinecarboxylic acid, 1,6-dimethoxy-, methyl ester

Produkt 1

HCID 84696473HCID 84696473, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

500 mg (2.02 mmol) 1,6-dimethoxy-isoquinoline-3-carboxylic acid methyl ester was dissolved in 20 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation, the residue taken up in water and acidified with 4 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and purified by HPLC.

Aufarbeitung

  1. customThe solvent was removed by distillation
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. custompurified by HPLC

Quellen und Nachweise

ORD-Eintrag
ord-9c1a3869d16e4b3b965d2666b7d5a2aa
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883789B2

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