Hydrochloric Acid → 4-bromo-1H-indazole

HRID 334101

Reaktionsgleichung

Reaktionsgleichung von HRID 334101
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][N:6]2C(=O)C.Cl>CO>[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 454801851-Acetyl-4-bromo-1H-indazole

Produkt 1

HCID 223525484-bromo-1H-indazole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of the 1-(4-bromo-indazol-1-yl)-ethanone A (3.09 g, 12.9 mmol) in MeOH (50 mL) was added 6N aqueous HCl (30 mL) and the mixture was stirred at room temperature for 7 h. The MeOH was evaporated and the mixture partitioned between EtOAc (2×50 mL) and water (50 mL). The combined organic layers were washed with brine (50 mL), separated and dried (MgSO4). The solvent was removed by evaporation under reduced pressure to give 4-bromo-1H-indazole B (2.36 g, 93%).

Aufarbeitung

  1. customThe MeOH was evaporated
  2. customthe mixture partitioned between EtOAc (2×50 mL) and water (50 mL)
  3. washThe combined organic layers were washed with brine (50 mL)
  4. customseparated
  5. dry with materialdried (MgSO4)
  6. customThe solvent was removed by evaporation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-513ff536127c4e6c862d7f38cd5632b5
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883799B2

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