Cyclohexane → HCID 178503531, Verbindung

HRID 334389Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 334389
[C:1]([C:3]1[C:4]([S:13][CH3:14])=[N:5][C:6]([OH:12])=[C:7]([CH:11]=1)C(O)=O)#[N:2].C1CCCCC1>C1(OC2C=CC=CC=2)C=CC=CC=1>[OH:12][C:6]1[CH:7]=[CH:11][C:3]([C:1]#[N:2])=[C:4]([S:13][CH3:14])[N:5]=1

Komponenten

4

Edukt 2

HCID 8078CyclohexaneHCID 178503561HCID 178503561, Verbindung

Produkt 1

HCID 178503531HCID 178503531, VerbindungAusbeute 60,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7583Diphenyl EtherLösungsmittel

Versuchsvorschrift

A solution of 6 g (28.5 mmol) of 5-cyano-2-hydroxy-6-(methylthio)nicotinic acid in 35 ml of diphenyl ether is stirred at 250° C. for 4 hours. After returning to room temperature, 100 ml of cyclohexane is added and the reaction medium is triturated for 30 minutes. The solid formed is filtered, rinsed thoroughly with cyclohexane and then dried under vacuum to yield 2.87 g (60%) of 6-hydroxy-2-(methylthio)nicotinonitrile in the form of a brown powder.

Aufarbeitung

  1. customAfter returning to room temperature
  2. customthe reaction medium is triturated for 30 minutes
  3. customThe solid formed
  4. filtrationis filtered
  5. washrinsed thoroughly with cyclohexane
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9c82bafac76948f78e06455e4eaaae25
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883821B2

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