Potassium Carbonate → 4-{(4-(4-Chlorophenyl)pyridin-2-yl)amino}benzamide

HRID 33446

Reaktionsgleichung

Reaktionsgleichung von HRID 33446
CN(C)/[CH:3]=[CH:4]/[C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=O.[N+]([O-])(O)=O.[C:19]([NH:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH2:29])=[O:28])=[CH:25][CH:24]=1)(=[NH:21])N.[C:32](=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[CH:4]=[CH:3][N:21]=[C:19]([NH:22][C:23]3[CH:24]=[CH:25][C:26]([C:27]([NH2:29])=[O:28])=[CH:30][CH:31]=3)[CH:32]=2)=[CH:8][CH:9]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 5375260(E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-oneHCID 178512511HCID 178512511, Verbindung

Produkt 1

HCID 691976134-{(4-(4-Chlorophenyl)pyridin-2-yl)amino}benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one (0.10 g, 0.48 mmol), 4-(amidinoamino)benzamide nitrate (0.116 g, 0.48 mmol), and potassium carbonate (0.132 g, 0.96 mmol) in ethanol (10 ml) with was heated to 120° C. overnight in a sealed vessel. The reaction mixture was cooled to room temperature and the resulting solid was collected then washed with ethanol, water, and diethyl ether to provide the title compound as a beige solid, identical in all respects with the compound prepared in Example 1.

Aufarbeitung

  1. customthe resulting solid was collected
  2. washthen washed with ethanol, water, and diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-c9b5cb1024384becbb40de5f00186850
Quelldatensatz
uspto-grants-2008_09
Patentnummer
US07429599B2

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