Benzyl chloroformate → HCID 16778897, Verbindung

HRID 334525Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 334525
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([Cl:16])[CH:15]=1)[C:5]([NH:7][NH:8][C:9](=[O:12])[CH2:10][Cl:11])=O.C(Cl)(OCC1C=CC=CC=1)=O>C(Cl)Cl>[Cl:11][CH2:10][C:9]1[O:12][C:5]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:15]=[C:14]([Cl:16])[CH:13]=2)=[N:7][N:8]=1

Komponenten

4

Edukt 2

HCID 10387Benzyl chloroformateHCID 13365860HCID 13365860, Verbindung2×

Produkt 1

HCID 16778897HCID 16778897, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of compound 6 (1.0 g, 6.36 mmol) and Et3 N (0.96 g, 9.50 mmol) in DCM, was added CbzCl (1.30 g, 7.64 mmol) slowly. The mixture was stirred at ambient temperature overnight. Then TLC showed-compound 6 had disappeared. The mixture was washed with brine, dried with Na2SO4 and concentrated to give crude product 7 as a colorless oil which was used in the next step without any purification.

Aufarbeitung

  1. washThe mixture was washed with brine
  2. dry with materialdried with Na2SO4
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0cc6f20d13ab4dbe9ad7ef603987e5c1
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08883827B2

Notizen zur Reaktion

Wird geladen…